Tag

Antibiotic Discovery

All articles tagged with #antibiotic discovery

health-and-medicine1 year ago•4 min saved

"Non-Antibiotic Drug Discovery Through Machine Learning for Bacteria Eradication"

Researchers are exploring the potential of nonantibiotic drugs, such as those used to treat cancer, diabetes, and depression, to kill bacteria in different ways from standard antibiotics. A new machine learning method has been developed to identify how nonantibiotics kill bacteria and find new bacterial targets for antibiotics. By analyzing almost 2 million instances of toxicity between 200 drugs and thousands of mutant bacteria, the researchers found that nonantibiotic and antibiotic drugs have different ways of killing bacterial cells. This approach has the potential to address the critical bottleneck in developing antibiotics and uncover new ways to fight bacterial infections and antibiotic resistance.

via ScienceAlert|

#antibiotic-discovery #antibiotic-resistance #bacteria

health1 year ago•4 min saved

"Non-Antibiotic Drugs' Bactericidal Effects Uncovered by Innovative Technique"

Nonantibiotic drugs, such as those used to treat cancer, diabetes, and depression, have been found to have antibacterial properties at typical prescribed doses. A new machine learning method has been developed to identify how these nonantibiotic drugs kill bacteria, potentially leading to the discovery of new antibiotic targets. This method has the potential to address the bottleneck in developing antibiotics and offers new opportunities to fight bacterial infections and antibiotic resistance.

via The Conversation Indonesia|

#antibiotic-discovery #antibiotics #bacteria

healthscience2 years ago•5 min saved

"Novel Antibiotic Eradicates Drug-Resistant Superbug"

A new synthetic compound, zosurabalpin, has been discovered as a promising antibiotic against the drug-resistant bacterial species CRAB (carbapenem-resistant Acinetobacter baumannii). This novel antibiotic targets CRAB using a unique attack strategy, disrupting the bacterium's outer membrane machinery. The compound is currently undergoing early-stage safety trials in humans and shows potential as a new class of antibiotic with a narrow target, reducing the impact on the body's microbiome. The discovery raises the possibility of LPS as a promising new target for future antibiotics against other gram-negative bacteria.

via Livescience.com|

#antibiotic #antibiotic-discovery #bacteria

science-and-technology2 years ago•20 min saved

Unveiling Antibiotic Discovery Breakthroughs in Pseudomonas

Researchers have discovered a porin-independent accumulation mechanism in Pseudomonas bacteria that enables the discovery of new antibiotics. Porins are outer membrane proteins that regulate the entry of molecules into the bacterial cell, and their presence has been a major barrier to developing effective antibiotics. By bypassing the need for porins, the researchers were able to identify compounds that accumulate in Pseudomonas cells and exhibit broad-spectrum antibacterial activity. This discovery opens up new possibilities for combating drug-resistant Gram-negative bacteria.

via Nature.com|

#antibiotic-discovery #drug-resistance #gram-negative-bacteria

health2 years ago•8 min saved

HMS Researcher Secures $104 Million Federal Project to Combat Antibiotic Resistance

Harvard Medical School researcher Johan Paulsson will lead a $104 million federal project funded by the Advanced Research Projects Agency for Health (ARPA-H) to study bacterial behavior and antibiotic resistance. The project aims to develop technology for improved diagnosis of bacterial infections, accelerate the discovery of new antibiotics, and enhance understanding of bacterial behavior. The research will involve scientists from 25 research groups across multiple institutions and will utilize microscopy, microfluidics, single-cell assays, and machine learning tools. The project has the potential to revolutionize the diagnosis and treatment of bacterial infections and address the growing threat of antibiotic resistance.

via Harvard Medical School|

#antibiotic-discovery #antibiotic-resistance #bacterial-behavior