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Zoonomia Project

All articles tagged with #zoonomia project

science2 years ago

Uncovering the Genomic Connection between Humans and Other Mammals.

The Zoonomia Project, an international effort led by Elinor Karlsson and Kerstin Lindblad-Toh, has discovered that certain areas of genetic information have stayed the same throughout evolution. The scientists looked at 240 species of mammals and found 4,552 genomic elements that are the same across mammal species and were identical in 235 of the 240 species. The unchanged parts might serve a purpose and may be “regulatory elements” that contain commands directing how much protein is produced and where and when it is produced. The findings on hibernation genetics could help with human therapies, intensive care, and even space flight.

science2 years ago

Genetic research uncovers our shared ancestry with animals.

The Zoonomia Project, an international effort comparing the genetic blueprints of an array of animals, has revealed that certain passages in the instructions for life have persisted across evolutionary time, representing a through line that binds all mammals, including humans. The project offers clues about human traits and diseases, animal abilities like hibernation, and even the genetics behind a sled dog named Balto who helped save lives a century ago. The findings come from 11 papers published in the journal Science, which tackle deep questions about the wonder of biology and how we are similar and dissimilar to all the things around us.

science2 years ago

Revolutionizing our understanding of mammals through genomic research.

Researchers from the Texas A&M School of Veterinary Medicine and Biomedical Sciences have used the largest mammalian genomic dataset in history to determine the evolutionary history of mammals over the last 100 million years. The study, part of the Zoonomia Project, concludes that mammals began diversifying before the extinction of non-avian dinosaurs, as a result of continental drifting, and another pulse of diversification occurred immediately following the extinction. The research is crucial to the goals of the Zoonomia Project, which aims to harness the power of comparative genomics as a tool for human medicine and biodiversity conservation.

science2 years ago

"240 Mammal Genomes Unravel Secrets of Human DNA"

The Zoonomia Project has compared DNA sequences from 240 mammalian species to identify key parts of the human genome that have remained unchanged for millions of years, shedding light on disease susceptibility and unique mammalian traits. The findings offer potential for improved disease understanding and biodiversity conservation. The researchers identified regions of the genomes that are most conserved across mammalian species and millions of years of evolution, pinpointed species that may be particularly susceptible to extinction, and identified genetic variants that are more likely to play causal roles in rare and common human diseases.

science2 years ago

Genome of Famous Sled Dog Balto Sequenced by Scientists

Scientists have sequenced the genome of Balto, the famous sled dog who led his team on the last leg of a 127-hour dogsled relay across Alaska to bring lifesaving medicine to the people of Nome in 1925. The study found that Balto was just part Siberian husky and not part wolf, contrary to popular legend. The genome sequencing sheds light on why Balto and similar sled dogs from that period proved well-suited to thrive in the harsh winter environment. The findings are part of the Zoonomia Project, an international collaboration to sequence and compare the genomes of 240 mammals.