Zebrafish Model News

science-and-health2 years ago•2 min saved

Unlocking the Brain's Potential with Omega-3 Fatty Acids.

Researchers at UCLA, Howard Hughes Medical Institute, and NIH have developed a zebrafish model to study how the brain acquires essential omega-3 fatty acids, including DHA and ALA, and how they pass through the blood-brain barrier via the lipid transporter Mfsd2a. The study provides images of the structure of zebrafish Mfsd2a, which is similar to its human counterpart, and identifies three compartments in Mfsd2a that suggest distinct steps required to move and flip fatty acids through the transporter. The findings may aid in the design of targeted drug delivery into the brain and central nervous system.

via SciTechDaily|

#blood-brain-barrier #drug-delivery #lipid-transport

science2 years ago•3 min saved

Brain's Omega-3 Fatty Acid Acquisition Model Developed by Researchers.

Researchers at the National Institutes of Health and colleagues have developed a zebrafish model that provides new insight into how the brain acquires essential omega-3 fatty acids, including docosahexaenoic acid (DHA) and linolenic acid (ALA). Their findings have the potential to improve understanding of lipid transport across the blood-brain barrier and of disruptions in this process that can lead to birth defects or neurological conditions. The model may also enable researchers to design drug molecules that are capable of directly reaching the brain.

via National Institutes of Health (.gov)|

#blood-brain-barrier #drug-delivery #mfsd2a

neuroscience2 years ago•3 min saved

Unlocking the Mystery: Omega-3 Fatty Acids and the Blood-Brain Barrier.

Researchers have developed a zebrafish model that sheds light on how the brain acquires essential omega-3 fatty acids, including DHA and ALA, and how the lipid transporter Mfsd2a transports these fatty acids across the blood-brain barrier. The study provides detailed images of the structure of Mfsd2a and identifies three compartments that suggest distinct steps required to move and flip fatty acids through the transporter. The findings could help in designing drug molecules capable of directly reaching the brain and shed light on disruptions that can lead to neurological conditions.

via Neuroscience News|

#blood-brain-barrier #drug-delivery #mfsd2a

neuroscience2 years ago•3 min saved

Unlocking the Brain-Boosting Benefits of Omega-3 Fatty Acids

Researchers have developed a zebrafish model that sheds light on how the brain acquires essential omega-3 fatty acids, including DHA and ALA, and how the lipid transporter Mfsd2a transports these fatty acids across the blood-brain barrier. The study provides detailed images of the structure of Mfsd2a and identifies three compartments that suggest distinct steps required to move and flip fatty acids through the transporter. The findings could help in designing drug molecules capable of directly reaching the brain and shed light on disruptions that can lead to neurological conditions.

via Neuroscience News|

#blood-brain-barrier #drug-delivery #mfsd2a