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Mfsd2a

All articles tagged with #mfsd2a

health2 years ago

Omega-3 Transporter Crucial for Myelin Production in MS.

A protein called Mfsd2a, which transports molecules that contain omega-3 fatty acids, is essential for regulating cells that make the fatty coating on nerve fibers, or myelin sheath, that’s damaged in multiple sclerosis (MS), a study indicates. In mice lacking Mfsd2a, the cells that make myelin, or oligodendrocytes, fail to mature, leading to a decline in cellular levels of omega-3 fatty acids and a reduction in myelination. The study opens up potential avenues to develop therapies and dietary supplements based on omega-3 that might help retain myelin in the aging brain and possibly to treat patients with neurological disorders stemming from reduced myelination.

via Multiple Sclerosis News Today|
#health#mfsd2a#ms
science2 years ago

Brain's Omega-3 Fatty Acid Acquisition Model Developed by Researchers.

Researchers at the National Institutes of Health and colleagues have developed a zebrafish model that provides new insight into how the brain acquires essential omega-3 fatty acids, including docosahexaenoic acid (DHA) and linolenic acid (ALA). Their findings have the potential to improve understanding of lipid transport across the blood-brain barrier and of disruptions in this process that can lead to birth defects or neurological conditions. The model may also enable researchers to design drug molecules that are capable of directly reaching the brain.

via National Institutes of Health (.gov)|
#blood-brain-barrier#drug-delivery#mfsd2a
neuroscience2 years ago

Unlocking the Mystery: Omega-3 Fatty Acids and the Blood-Brain Barrier.

Researchers have developed a zebrafish model that sheds light on how the brain acquires essential omega-3 fatty acids, including DHA and ALA, and how the lipid transporter Mfsd2a transports these fatty acids across the blood-brain barrier. The study provides detailed images of the structure of Mfsd2a and identifies three compartments that suggest distinct steps required to move and flip fatty acids through the transporter. The findings could help in designing drug molecules capable of directly reaching the brain and shed light on disruptions that can lead to neurological conditions.

via Neuroscience News|
#blood-brain-barrier#drug-delivery#mfsd2a
neuroscience2 years ago

Unlocking the Brain-Boosting Benefits of Omega-3 Fatty Acids

Researchers have developed a zebrafish model that sheds light on how the brain acquires essential omega-3 fatty acids, including DHA and ALA, and how the lipid transporter Mfsd2a transports these fatty acids across the blood-brain barrier. The study provides detailed images of the structure of Mfsd2a and identifies three compartments that suggest distinct steps required to move and flip fatty acids through the transporter. The findings could help in designing drug molecules capable of directly reaching the brain and shed light on disruptions that can lead to neurological conditions.

via Neuroscience News|
#blood-brain-barrier#drug-delivery#mfsd2a