All articles tagged with #t cell exhaustion
Originally Published 3 months ago — by Nature
The study reveals that proteotoxic stress response (PSR) drives T cell exhaustion in cancer, characterized by increased protein synthesis, chaperone activation, and protein aggregation, with sustained AKT activity as a key upstream driver. Targeting specific chaperones like gp96 and BiP can mitigate exhaustion and improve immunotherapy outcomes.
Originally Published 2 years ago — by Nature.com
A new study has found that the β1-adrenergic receptor, which links sympathetic nerves to immune cells, plays a crucial role in T-cell exhaustion. T-cell exhaustion is a state of dysfunction that limits the immune response against cancer and chronic infections. The researchers discovered that blocking the β1-adrenergic receptor improved T-cell priming and enhanced the efficacy of cancer vaccines. This finding provides insights into the mechanisms of T-cell exhaustion and suggests potential therapeutic targets for improving immune responses in cancer immunotherapy.