All articles tagged with #protein clearance
Fasting triggers the production of ketone bodies like β‑hydroxybutyrate, which can bind to misfolded proteins in the brain, promoting their removal and potentially improving brain health and memory, with promising results in animal studies and early human trials.
Research from the Buck Institute reveals that ketone bodies, particularly β-hydroxybutyrate, can aid in clearing damaged proteins in the brain by altering their solubility and promoting autophagy. This discovery, tested in mouse models of Alzheimer's and aging, suggests a new metabolic link to neurodegeneration and aging, offering potential therapeutic pathways. The study highlights ketone bodies as signaling metabolites that improve brain health beyond their energy-providing role during fasting.
Researchers at MIT have demonstrated that stimulating high-frequency brain waves in mice with flashes of light and clicks of sound at 40 hertz can clear amyloid proteins associated with Alzheimer's. This stimulation increased protective cerebrospinal fluid, pulsations in neighboring arteries, and interstitial fluid leaving the brain, all aiding in waste removal. The study also highlighted the role of aquaporin-4 channels in astrocyte cells and an increase in a peptide linked to combating Alzheimer's. These findings provide valuable insights for understanding Alzheimer's and potentially reversing its effects by enhancing the brain's waste removal system.