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Nucleolus

All articles tagged with #nucleolus

science1 year ago

Compact Nucleolus: A Potential Key to Anti-Aging

Researchers at Weill Cornell Medicine have discovered that maintaining a small nucleolus within cells may delay aging, as demonstrated in yeast. The study, published in Nature Aging, suggests that smaller nucleoli, achieved by tethering ribosomal DNA to the nuclear membrane, can extend lifespan similarly to calorie restriction. This finding could lead to new treatments for age-related diseases by preventing genomic instability associated with enlarged nucleoli. Future research will explore these effects in human stem cells.

via Phys.org|
#aging#cell-biology#genomic-stability
science-and-technology2 years ago

Decoding the Evolutionary Secrets of the Nucleolus: MIT's Breakthrough

MIT biologists have discovered that a protein called TCOF1 is responsible for the formation of a biomolecular condensate known as the fibrillar center within the nucleolus, a cell organelle involved in building ribosomes. This finding sheds light on an evolutionary shift that occurred around 300 million years ago, where the nucleolus developed a third compartment in amniotes. The researchers hypothesize that TCOF1 played a crucial role in this transition. Understanding the formation and function of condensates could have implications for studying other cellular processes and diseases associated with biomolecular condensates.

via SciTechDaily|
#biomolecular-condensates#evolution#mit
science-and-technology2 years ago

"The Evolutionary Origins of a Nucleolar Component Unveiled by Study"

MIT biologists have discovered that a protein called TCOF1 is responsible for the formation of a condensate within the nucleolus, a cell organelle involved in building ribosomes. The researchers found that TCOF1 is essential for the transition from a bipartite to a tripartite nucleolus, which occurred around 300 million years ago. The study suggests that TCOF1 acts as a scaffold protein, helping to organize the nucleolus and attract other proteins and biomolecules. The findings shed light on the evolution of biomolecular condensates and could have implications for understanding diseases associated with their formation.

via MIT News|
#biomolecular-condensates#evolution#nucleolus