All articles tagged with #immune modulation
Researchers showed that common gut bacteria have type III secretion systems that inject proteins into human cells, altering immune signaling (including NF-κB and cytokine responses); these interactions are enriched in Crohn’s disease microbiomes, suggesting commensals can actively shape inflammation and may help explain microbiome–disease links while guiding future therapies.
A clinical trial has been launched by the National Institutes of Health (NIH) to test the effectiveness of early intensive immune modulation for hospitalized COVID-19 patients with mild illness. The trial, part of the global clinical trials consortium known as STRIVE, aims to enroll approximately 1,500 participants at research sites worldwide. The study will investigate whether adding a second therapeutic earlier in the patient's treatment can prevent progression to severe illness and improve recovery. The drug being tested is abatacept, which is believed to be useful as an immune modulator for COVID-19 by suppressing overactive immune responses. The trial will monitor patient safety and assess the benefits of early immune modulator intensification.
Inhaling menthol has been found to enhance cognitive abilities and modulate immunity in animal models of Alzheimer's disease, according to a study by researchers at Cima University of Navarra in Spain. The study suggests that frequent exposure to menthol can adjust the immune response and prevent cognitive decline associated with Alzheimer's. The researchers also found that blocking the activity of certain immune cells improved cognitive ability in mice with Alzheimer's. These findings highlight the potential of scent-based therapies and immune modulators in the treatment of neurodegenerative disorders.