Tag

Gaba Receptors

All articles tagged with #gaba receptors

science1 year ago•6 min saved

Decoding the Secrets of GABA Receptors

New research using cryogenic electron microscopy has uncovered the vast diversity of Type-A GABA receptors (GABAARs), identifying over 324,000 potential structures influenced by subunit combinations. These variations affect receptor function and drug binding, offering insights for developing targeted therapies that enhance specific receptor functions without causing tolerance or dependence. The study highlights the importance of understanding receptor assembly for improving treatments for conditions like anxiety, seizures, and postpartum depression.

via Neuroscience News|

#brain-balance #cryogenic-electron-microscopy #drug-development

neuroscience2 years ago•5 min saved

Unraveling the Link Between GABA Receptors and Antidepressant Efficacy

GABA receptors and the neurotransmitter GABA have been identified as potential therapeutic targets for managing depressive disorders. Both drugs that enhance and inhibit GABA-A receptor activity could have antidepressant effects, suggesting the complexity of depression treatment mechanisms. The authors propose possible pathways through which GABA-modulating treatments could alleviate cognitive and affective symptoms associated with depression. Additionally, GABA-A receptors may also play a role in treating cognitive impairment often correlated with depression. The research highlights the importance of GABA receptors in depression and their potential as crucial targets for both affective and cognitive symptoms.

via Neuroscience News|

#antidepressant-targets #cognitive-symptoms #depression-treatment