Unraveling the Link Between GABA Receptors and Antidepressant Efficacy

GABA receptors and the neurotransmitter GABA have been identified as potential therapeutic targets for managing depressive disorders. Both drugs that enhance and inhibit GABA-A receptor activity could have antidepressant effects, suggesting the complexity of depression treatment mechanisms. The authors propose possible pathways through which GABA-modulating treatments could alleviate cognitive and affective symptoms associated with depression. Additionally, GABA-A receptors may also play a role in treating cognitive impairment often correlated with depression. The research highlights the importance of GABA receptors in depression and their potential as crucial targets for both affective and cognitive symptoms.