Decoding the Secrets of GABA Receptors

New research using cryogenic electron microscopy has uncovered the vast diversity of Type-A GABA receptors (GABAARs), identifying over 324,000 potential structures influenced by subunit combinations. These variations affect receptor function and drug binding, offering insights for developing targeted therapies that enhance specific receptor functions without causing tolerance or dependence. The study highlights the importance of understanding receptor assembly for improving treatments for conditions like anxiety, seizures, and postpartum depression.