Mapping the Complexity: Unveiling the Multi-Omic Atlas of the Mouse Brain

Researchers have created a comprehensive atlas of the adult mouse brain, mapping the DNA methylome and 3D genome at single-cell resolution. The study utilized enhanced single-nucleus methylation sequencing and chromatin conformation capture sequencing to analyze DNA methylomes and the 3D genome in detail. The dataset identified 4,673 cell groups and provided a multi-omic resource for understanding the molecular architecture of the mouse brain. The study deepens insights into the epigenetic and transcriptomic intricacies that underpin brain function and diseases.