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Dupuytrens Disease

All articles tagged with #dupuytrens disease

health2 years ago•2 min saved

Uncovering the Genetic Roots of "Viking Disease" through the Neanderthal Handshake.

Dupuytren's disease, a hand disorder common among Northern Europeans, has been found to have genetic links to Neanderthals. Three of the 61 genetic risk variants for the disease identified by researchers are of Neanderthal origin, highlighting the influence of ancient ancestry on modern health issues. The condition is much more common in people of Northern European ancestry, and the finding that two of the most important genetic risk factors for Dupuytren’s disease are of Neanderthal origin leads the scientists to conclude that Neanderthal ancestry is a significant factor in explaining the prevalence of the disease in Europe today.

via SciTechDaily|

#dupuytrens-disease #genetic-risk-factors #hand-disorder

health2 years ago•3 min saved

Neanderthal DNA linked to hand disorder and longevity breakthrough.

Neanderthal genes may be one cause of Dupuytren's disease, a disorder in which fingers become frozen in a bent position, according to a new study. The study finds gene variants that were inherited from Neanderthals that dramatically increase the odds of developing the condition. The researchers discovered that, of the 61 variants, three variants were of Neanderthal origin, of which two were very strongly linked to the disease. The Neanderthal gene most strongly linked to the disease, called EPDR1, sits on chromosome 7. The study has implications for future targeted therapy.

via Livescience.com|

#dupuytrens-disease #epdr1-gene #genetic-risk

health2 years ago•2 min saved

The Neanderthal Connection to Viking Disease and Our Health Today

A new study has found that interbreeding with Neanderthals 40,000 years ago has left a genetic inheritance that affects our health today. Researchers found that a Neanderthal gene variant increases the risk of dying from COVID-19, while another increases the risk of developing Dupuytren's disease, a condition where fingers are permanently bent. The study suggests that up to 30% of men over 60 in northern Europe suffer from Dupuytren's disease due to inherited DNA from Neanderthal ancestors. Only 7% of the human genome is unique to Homo sapiens, with brain development and function setting us apart.

via Business Insider|

#covid-19 #dupuytrens-disease #genetic-inheritance

science2 years ago•5 min saved

Neanderthal Ancestry Linked to "Viking Disease" Hand Condition

Researchers have found a link between Neanderthal genetic material and Dupuytren’s disease, also known as Viking’s disease, a hand condition that can cause some of a person’s fingers to become permanently bent at an angle. Neanderthals living 40,000 to 50,000 years ago suffered from some form of this condition and passed this vulnerability on to humans living alongside them in Northern Europe. The name “Viking disease” comes from its predominance among descendants of the ancient Viking warriors who once ruled Scandinavia. Studies have shown that about two percent of the human genome is comprised of DNA sourced from distant Neanderthal ancestors, impacting human health and development.

via Ancient Origins|

#dupuytrens-disease #genetic-material #interbreeding

health2 years ago•2 min saved

Neanderthal Genes Linked to 'Viking Disease' Hand Disorder

A new study shows that Dupuytren's disease, a hand disorder that causes permanent bending of the fingers, is partly of Neanderthal origin. The disease is much more common in Northern Europeans than in those of African ancestry. Researchers used data from over 7,000 cases and 645,000 controls to identify genetic risk variants for the disease and found that two of the most important genetic risk factors are of Neanderthal origin, leading them to conclude that Neanderthal ancestry is a significant factor in explaining the prevalence of the disease in Europe today.

via Phys.org|

#dupuytrens-disease #genetic-risk-factors #hand-disorder