All articles tagged with #drug therapy
UVA researchers have identified a physiological cause of memory loss in Alzheimer's, involving protective 'nets' around neurons in the hippocampus, and found a drug used for cancer and arthritis that may prevent this loss in mice. Human trials are still years away, but the findings could lead to new treatments for Alzheimer's disease.
A Stanford-led study in mice suggests that inhibiting the overactive LRRK2 enzyme, linked to a common genetic mutation in Parkinson's disease, can restore damaged brain cells and improve neuronal communication, offering hope for early treatment and potential benefits for other neurodegenerative diseases.
Researchers from Mount Sinai and City of Hope have developed a drug therapy that significantly increases the number of insulin-producing beta cells in the pancreas, potentially curing diabetes. Using harmine and a GLP1 receptor agonist, the therapy increased beta cell numbers by 700% in mice, effectively reversing diabetes. This breakthrough offers hope for future regenerative therapies to treat diabetes in humans, though further trials and solutions to immune response issues are needed.
A late-stage trial by Novartis has shown that the drug Kisqali, used in people with early-stage HR+/HER2- breast cancer, significantly reduces the risk of the cancer returning after treatment. The trial was a randomized controlled trial of 4,000 patients at 425 sites in 21 countries. Kisqali improved the percentage of people with invasive disease-free survival to 90.4% at three years, compared with 87.1% without it. Side effects included elevated liver enzymes, diarrhea and neutropenia. The drug is priced up to $15,000 a month.
Hyperbaric oxygen therapy (HBOT) is more effective in treating fibromyalgia resulting from traumatic brain injury (TBI) than drug therapy, according to a study by Tel Aviv University. The study found that HBOT is much more effective in reducing pain than drug treatment, and it even resulted in the complete recovery of two out of five patients. Fibromyalgia is a chronic pain syndrome that damages the brain’s processing of signals received from the body. HBOT can heal the damaged brain tissue and not just treat its superficial symptoms.