"Silent Alzheimer's: Unraveling the Symptom-Free Brain"
Researchers in the Netherlands discovered a subgroup of individuals with Alzheimer's pathology in their brains who never exhibited symptoms, suggesting resilience due to factors like genetics, lifestyle, and cognitive activities. This resilience may involve protective brain mechanisms such as increased antioxidant production by astrocytes and a more effective unfolded protein response. The findings highlight the potential for cognitive reserve to delay or prevent the onset of Alzheimer's symptoms despite the presence of disease markers.