All articles tagged with #brain initiative
A team led by Tomasz Nowakowski is creating the first detailed map of the human brain's development from embryo to adulthood, aiming to better understand mental disorders and brain formation using advanced technologies and cell analysis, building on historical and recent neuroscience research.
Researchers have conducted a single-cell analysis of chromatin accessibility in the adult mouse brain, aiming to understand the cellular and molecular composition of the mammalian brain. By using the single-nucleus assay for transposase-accessible chromatin followed by sequencing (snATAC-seq), they profiled chromatin accessibility at the single-cell resolution across the entire adult mouse brain. The study identified 1,482 brain cell types and annotated 1 million cis-regulatory elements (cCREs) responsible for gene expression patterns in each cell type. The findings provide insights into gene regulation and function in different brain cell types, advancing our understanding of brain development and neurological disorders.
Scientists have created detailed cell maps of the human brain and the nonhuman primate brain, providing a deeper understanding of brain structure and function. The maps, funded by the National Institutes of Health's BRAIN Initiative, offer insights into the cellular basis of brain disorders and pave the way for precision therapeutics. The studies reveal the complex diversity of cells in the brain, identify similarities and differences between human and nonhuman primate brains, and explore the link between cellular properties and brain development. The findings serve as a foundation for designing new therapies that target specific brain cells and circuits involved in brain disorders.