Unraveling the Genetic Ties Between Emotions and Addiction

Researchers at the Medical University of South Carolina have discovered a genetic mechanism involving R-loops, RNA:DNA structures, that regulate behavioral adaptations to emotional experiences by activating genes like NPAS4. This mechanism, which can prevent maladaptive behaviors such as drug-seeking and stress-induced anhedonia in mice, highlights the potential for RNA-based therapies to treat psychiatric disorders linked to stress and substance use.