Forever chemicals may age men faster in their 50s, new research suggests

A Frontiers in Aging study links PFAS “forever chemicals”—present in the blood of about 98% of Americans—to accelerated epigenetic aging, with the strongest effects in men aged 50–65. Using NHANES data from 1999–2000 and 11 PFAS measured in blood, researchers found sex-specific associations and smaller signals in women. Experts caution the findings show associations, not causation, and regulatory bodies describe them as exploratory. Practical reductions in exposure (such as certified water filters and limiting contact with stain- or grease-resistant materials) are considered reasonable, though complete avoidance is unlikely; broader regulatory actions may be needed to curb PFAS exposure.