"Long-lasting Cholesterol Reduction in Mice Using Epigenetic Gene Silencing"

Scientists have successfully reduced cholesterol levels in mice by using an alternative to genome editing that targets the epigenome, altering chemical tags on DNA without changing the DNA sequence. The study, published in Nature, demonstrates the potential for treating diseases by editing the epigenome, avoiding the risks associated with altering DNA. The findings have sparked excitement in the field of epigenetic editing, with several companies focusing on developing therapies, and a clinical trial underway for an epigenetic editor targeting a gene overactive in many cancers.