Unveiling Epigenetic Regulation in 11 Tumor Types during Cancer Transitions

A study has constructed an integrative multi-omic atlas of 11 major cancer types, providing a unified map of lineage-specific and cancer-specific cell populations, differentially accessible enhancers and promoters, epigenetically regulated cancer-associated genes, and transcription factors (TFs) that are important across major cancer transitions. The research highlights the potential of TFs as prognostic markers and offers a deeper understanding of the molecular underpinnings driving cancer evolution. The study also identifies epigenetic changes and genetic mutations that cooperate in cancer transition programs, and reveals the regulatory relationships between chromatin accessibility and gene transcription in cancer cells.