All articles tagged with #tumor progression
University of South Alabama researchers discovered that neurons can transfer mitochondria directly to cancer cells via tunneling nanotubes, enhancing their energy production, resistance, and metastatic potential. Disrupting nerve input reduced tumor invasiveness, suggesting targeting nerve-cancer interactions could be a promising strategy to limit cancer spread.
A study has constructed an integrative multi-omic atlas of 11 major cancer types, providing a unified map of lineage-specific and cancer-specific cell populations, differentially accessible enhancers and promoters, epigenetically regulated cancer-associated genes, and transcription factors (TFs) that are important across major cancer transitions. The research highlights the potential of TFs as prognostic markers and offers a deeper understanding of the molecular underpinnings driving cancer evolution. The study also identifies epigenetic changes and genetic mutations that cooperate in cancer transition programs, and reveals the regulatory relationships between chromatin accessibility and gene transcription in cancer cells.
Researchers have discovered that pharmacological targeting of netrin-1, a protein involved in tumor progression and metastasis, can inhibit epithelial-mesenchymal transition (EMT) in cancer. EMT is a process that allows cancer cells to acquire invasive and migratory properties, contributing to tumor metastasis. Netrin-1 has been found to promote EMT and is associated with poor prognosis in various types of cancer. By interfering with netrin-1, it may be possible to inhibit EMT and potentially limit cancer progression and metastasis.