Advancements in Immunotherapy Unveil Immune System's Impact on Tumor Development

Yale researchers have developed a new method to study the complex interactions between a person's immune system and tumor cells, which can influence cancer progression and treatment response. The technique involves recreating a patient's specific tumor microenvironment in mice using immune precursor cells collected from bone marrow samples. This personalized approach allows researchers to model an individual patient's tumor and immune system in the same mouse, enabling a better understanding of how the tumor microenvironment influences cancer growth and how individual differences affect the process. The method also has potential applications in drug testing and screening for new drug combinations.