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Shlp2

All articles tagged with #shlp2

health-science2 years ago•2 min saved

"Discovery of Rare Gene Mutation Halves Parkinson's Disease Risk"

Researchers have discovered a rare genetic mutation in a small protein, SHLP2, that halves the risk of developing Parkinson's disease, primarily found in people of European descent. This mutation is associated with better protection against mitochondrial dysfunction, a key factor in the disease. The discovery could lead to new treatments for Parkinson's and sheds light on the potential of exploring mitochondrial-derived microproteins for preventing and treating age-related diseases.

via New York Post |

#genetic-mutation #health-science #mitochondrial-dysfunction

health-and-medicine2 years ago•3 min saved

"Rare Genetic Variant Linked to Lower Parkinson's Risk Sparks Therapeutic Hope"

Researchers at the USC Leonard Davis School of Gerontology have identified a rare genetic mutation in a mitochondrial microprotein called SHLP2 that significantly reduces the risk of developing Parkinson's disease. Found primarily in Europeans, this mutation is associated with a twofold decrease in disease risk and offers a new target for potential treatments. The study, published in Molecular Psychiatry, shows that the variant increases the stability and expression of SHLP2, enhancing its protective effects against mitochondrial dysfunction, a key factor in Parkinson's disease. This discovery opens up new avenues for understanding and treating age-related diseases.

via Medical Xpress|

#genetics #health-and-medicine #mutation