All articles tagged with #scripps research institute
A compound called LY2444296 has shown promise in blocking alcohol cravings by targeting the kappa opioid receptor (KOP) in the brain, according to research conducted in mice at the Scripps Research Institute. The compound reduced alcohol withdrawal symptoms in mice, raising hopes for a potential therapy for alcohol use disorder. However, further study is needed to determine its effectiveness and safety in humans.
Scientists at Scripps Research Institute have identified a potential universal antivenom for snakebites by screening human antibodies and discovering one that counteracts a protein in venom found in various snake species. The antibody, called 95Mat5, protected mice against venom from snakes including king cobras and black mambas. This breakthrough could be crucial for low and middle-income countries with high snakebite burdens, as existing antivenoms are specific to individual snake species. The researchers are now pursuing other broadly neutralizing antibodies to potentially create a universal antivenom cocktail against medically relevant snake venoms.
Researchers at Scripps Research have developed a new technology using optogenetics to track the deactivation of neurons, shedding light on how the brain regulates activity through inhibition. By identifying rapid changes in the pyruvate dehydrogenase (PDH) protein immediately after brain cells stop firing, the team has opened new avenues for studying brain cell inhibition and its role in various diseases, including depression, PTSD, and Alzheimer’s. This groundbreaking technique provides a deeper understanding of normal brain functions and offers potential insights for treating a range of brain disorders and metabolic diseases.