Tag

Retinal Diseases

All articles tagged with #retinal diseases

business1 year ago•8 min saved

Merck Eyes $3B Acquisition of EyeBio for Ophthalmology Expansion

Merck is set to acquire EyeBio, an ophthalmology-focused biotech company, for up to $3 billion, including an upfront payment of $1.3 billion and potential milestone payments. The acquisition includes EyeBio's lead candidate, Restoret™, which targets diabetic macular edema and neovascular age-related macular degeneration, and is expected to enter pivotal trials in late 2024. This move aims to expand Merck's pipeline and presence in ophthalmology.

via Merck|

#acquisition #business #eyebio

health1 year ago•2 min saved

"Gut Bacteria's Role in Inherited Eye Diseases Revealed"

Research suggests that gut bacteria may play a role in causing some genetic eye diseases, prompting hopes that antibiotics could be used to treat these conditions. A study found that mutations in the CRB1 gene weaken protective barriers around the eye and the colon, leading to distorted cell layers in the retina. Treating mutant mice with antibiotics reduced eye damage, raising the possibility of similar treatments for people with CRB1 mutations. However, some experts caution that the results may not directly translate to humans and that genetic changes caused by CRB1 could still be harmful, even in the absence of bacteria.

via Nature.com|

#antibiotics #eye-diseases #genetic-diseases

science-and-research1 year ago•4 min saved

"Comparing Human and Insect Vision: Surprising Revelations"

Researchers at the University of California, Irvine, have uncovered significant differences in the production of 11-cis-retinal, a crucial molecule for vision, between humans and insects. Their study challenges traditional assumptions about the similarities and differences of human and insect vision, shedding light on the genetic basis of retinal diseases like Leber congenital amaurosis. By studying the NinaB protein in insects and comparing it to the human RPE65 protein, the team gained insights into the unique processes underlying 11-cis-retinal production, offering potential pathways for addressing genetic mutations that impair vision.

via Neuroscience News|

#11-cis-retinal #human-insect-comparison #neuroscience

health2 years ago•3 min saved

The Crucial Role of Eye Color Genes in Retinal Health

A study by researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, has found that genes responsible for eye color pigmentation also play a critical role in maintaining retinal health. The study focused on the kynurenine pathway, a metabolic pathway that regulates various biological processes, and found that the balance between toxic and protective metabolites within the pathway influences the health of the retina. The researchers suggest that therapeutic strategies for neurodegenerative conditions should take into account the ratio of various metabolites and their specific sites of accumulation and activity within the pathway.

via Medical Xpress|

#eye-health #gene-mutations #health