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Publication Bias

All articles tagged with #publication bias

health2 years ago

"Questioning the Efficacy of a Common Anxiety Pill: A Closer Look"

A re-evaluation of trials and studies on the efficacy of Xanax, a commonly prescribed anxiety medication, has found that its effectiveness may have been exaggerated by approximately 40 percent due to publication bias. While still more effective than a placebo, the drug's efficacy was inflated in published studies. Only one out of the five trials reviewed by the FDA was deemed positive, raising questions about the drug's actual effectiveness. Xanax, a benzodiazepine, is known for its addictive nature and potential side effects. The study highlights the need for further examination of the drug's efficacy and raises concerns about its widespread use.

via Daily Mail|
#anxiety#benzodiazepines#efficacy
health2 years ago

"Controversial Findings Challenge Xanax's Efficacy in New Study"

A new study published in Psychological Medicine suggests that the widely prescribed sedative alprazolam (Xanax XR) may be less effective than previously believed, with publication bias potentially inflating its efficacy by over 40%. The research examined both published and unpublished data from five randomized controlled clinical trials reviewed by the FDA for alprazolam. Benzodiazepines, including Xanax, have been associated with clinical risks such as dependence, withdrawal, falls, and cognitive impairment. The study's findings raise questions about the effectiveness of Xanax and highlight the need for caution when prescribing benzodiazepines.

via SciTechDaily|
#benzodiazepines#efficacy#health
health2 years ago

"Controversy Surrounding Xanax's Effectiveness"

A new study analyzing both published and unpublished clinical trial data has raised questions about the efficacy of alprazolam (Xanax XR), a widely prescribed benzodiazepine sedative. Out of the five FDA-reviewed trials, only one showed a clearly positive outcome. The study suggests that publication bias may have inflated the drug's effectiveness by over 40%. Researchers emphasize the need for caution when prescribing this medication, especially for first-time users.

via Neuroscience News|
#benzodiazepines#caution#efficacy
health2 years ago

Unveiling the Hidden Risks: Psychiatric Journals' Pro-Pharma Bias and Antidepressants

A study reveals that top psychiatry journals have a publication bias in favor of antidepressant studies with favorable results, which are more likely to be conducted by lead authors with financial ties to the pharmaceutical industry. Studies with unfavorable outcomes are often relegated to non-psychiatric or low-ranked journals. The researchers found that study quality did not explain this bias, indicating that top psychiatric journals tend to publish researchers funded by pharma, regardless of study quality. This biased publication creates a false image of the safety and efficacy of antidepressant drugs, potentially leading to a public health crisis of increased suicide deaths due to antidepressant use. Independent researchers conclude that antidepressants increase suicide risk, contrary to industry-sponsored studies.

via Mad in America|
#antidepressants#health#pharmaceutical-industry
science2 years ago

Unveiling the Truth: Bias and Exaggeration in Ecology

A study in the field of ecology has found empirical evidence of widespread exaggeration bias and selective reporting, highlighting concerns about the reproducibility of research findings in the discipline. The study examined the prevalence of these biases in ecological research and their potential impact on effect sizes, statistical power, and the occurrence of type M (magnitude) and type S (sign) errors. The findings suggest that publication bias and the pressure to report statistically significant results may contribute to the exaggeration of effect sizes and the suppression of non-significant findings. The study emphasizes the need for transparency, reproducibility, and improved statistical reporting practices in ecology to ensure the credibility and reliability of research findings.

via Nature.com|
#ecology#exaggeration-bias#publication-bias