All articles tagged with #pten
Researchers discovered that loss of the autism-linked gene PTEN in specific inhibitory neurons of the amygdala disrupts local brain circuits, leading to increased fear and anxiety behaviors in animal models, without affecting social or repetitive behaviors, providing insights into the neural basis of certain ASD traits.
Researchers have discovered that PI3Kβ plays a crucial role in immune evasion in PTEN-deficient breast tumors. The study found that inhibiting PI3Kβ led to increased immune cell infiltration and improved response to immunotherapy in mouse models. The findings suggest that targeting PI3Kβ could be a potential strategy for enhancing the effectiveness of immunotherapy in breast cancer patients with PTEN-deficient tumors.