All articles tagged with #protein protein interactions
The article discusses the design of protein systems that utilize facilitated dissociation to control the timing of cytokine signaling, enabling rapid and tunable regulation of protein interactions through allosteric mechanisms and structural strain, with applications in cellular signaling and biosensing.
BindCraft is a novel computational pipeline that leverages deep learning, specifically AlphaFold2, to de novo design functional protein binders targeting diverse proteins, including challenging membrane receptors, allergens, and nucleases, with high success rates and potential therapeutic applications.
Researchers have created multiple global atlases of inhibitory allosteric communication in KRAS, a protein involved in signaling pathways and a known therapeutic target. By quantifying the impact of over 26,000 mutations on the folding and binding of KRAS, the study identified allosteric sites that can be targeted for inhibition. The central beta sheet of KRAS was found to be particularly effective in allosteric propagation, and multiple surface pockets were validated as allosterically active, including a distal pocket in the C-terminal lobe of the protein. This research provides insights into the regulatory and therapeutic potential of allosteric modulation in proteins.
Scientists have created a detailed map of the spatial interactions between viral and host cell proteins within human cytomegalovirus (HCMV) particles, shedding light on the strategies used by herpes viruses to evade the immune system and replicate efficiently. The study revealed that certain host cell proteins are recruited by viral proteins, such as UL32, to aid in viral replication. This innovative technique of cross-linking mass spectrometry has provided valuable insights into the complex life cycle of HCMV and may contribute to the development of antiviral drugs against HCMV.