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Bindcraft

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BindCraft Enables One-Shot Design of Functional Protein Binders

Originally Published 4 months ago — by Nature

Featured image for BindCraft Enables One-Shot Design of Functional Protein Binders
Source: Nature

BindCraft is a novel computational pipeline that leverages deep learning, specifically AlphaFold2, to de novo design functional protein binders targeting diverse proteins, including challenging membrane receptors, allergens, and nucleases, with high success rates and potential therapeutic applications.

BindCraft AI Excels in One-Shot Protein Design

Originally Published 4 months ago — by Genetic Engineering and Biotechnology News

Featured image for BindCraft AI Excels in One-Shot Protein Design
Source: Genetic Engineering and Biotechnology News

BindCraft, an AI-powered pipeline for de novo protein binder design developed by EPFL researchers, achieves high success rates in creating functional protein binders against diverse targets, including challenging proteins like CRISPR-Cas9, with potential to accelerate drug discovery and therapeutic development. Its open-source availability has garnered widespread industry and academic adoption, marking a significant advancement in computational protein engineering.