BindCraft is a novel computational pipeline that leverages deep learning, specifically AlphaFold2, to de novo design functional protein binders targeting diverse proteins, including challenging membrane receptors, allergens, and nucleases, with high success rates and potential therapeutic applications.
BindCraft, an AI-powered pipeline for de novo protein binder design developed by EPFL researchers, achieves high success rates in creating functional protein binders against diverse targets, including challenging proteins like CRISPR-Cas9, with potential to accelerate drug discovery and therapeutic development. Its open-source availability has garnered widespread industry and academic adoption, marking a significant advancement in computational protein engineering.