Tag

Protein Dynamics

All articles tagged with #protein dynamics

science-and-technology1 year ago•4 min saved

"Revolutionary Protein Dynamics Prediction Technique Set to Transform Drug Discovery"

Researchers at Brown University have developed a machine learning technique to predict multiple protein configurations, allowing for a better understanding of protein dynamics and functions. This approach has the potential to revolutionize drug discovery by uncovering more targets for new treatments, particularly in targeted cancer therapy. The new method, which rapidly predicts multiple protein conformations, is accurate, fast, cost-effective, and could significantly accelerate the discovery time for understanding protein dynamics and conformations.

via Phys.org|

#computational-methods #drug-discovery #machine-learning

science-and-technology2 years ago•3 min saved

"Visualizing Protein Collapse: Unveiling the Critical Moments in Alzheimer's and Other Diseases"

Researchers have developed a new imaging technique to capture the moment when proteins associated with neurodegenerative diseases like Alzheimer's and ALS begin to aggregate. By closely monitoring the transition of proteins from their liquid to solid phase, the team observed the formation of dense protein condensates that eventually solidified into clumps. This breakthrough provides insights into the physical process underlying neurodegenerative diseases and could lead to a better understanding of protein interactions.

via ScienceAlert|

#imaging-techniques #neurodegenerative-diseases #protein-aggregation

science-and-technology2 years ago•37 min saved

Unveiling the Unpredictable: Exploring Extreme Dynamics in Biomolecular Condensates

Researchers studying biomolecular condensates have deposited simulation trajectories of the condensates at Zenodo and provided source data with their paper. They used a custom add-on package for Mathematica v.12.3 for the analysis of single-molecule fluorescence data and made the code available on GitHub. The code used to calculate the lifetime of residue-residue contacts is also available. The study contributes to the understanding of extreme dynamics in biomolecular condensates.

via Nature.com|

#biomolecular-condensates #data-availability #phase-separation