Tag

Myosin

All articles tagged with #myosin

science1 year ago•4 min saved

Breakthrough Protein Found to Halt Muscle Degeneration

Researchers have uncovered the role of the protein chaperone UNC45 in maintaining muscle health by managing myosin quality. UNC45 helps fold myosin correctly and tags faulty proteins for degradation, preventing muscle disorders. The study, using advanced techniques like crosslinking mass spectrometry and X-ray crystallography, reveals how UNC45 distinguishes between healthy and defective myosin, linking myosin quality control to muscle diseases such as Freeman Sheldon Syndrome. This research could lead to better understanding and treatment of myopathies.

via SciTechDaily|

#muscle-health #myopathies #myosin

biology1 year ago•5 min saved

Uncovering the Molecular Mechanisms of Mammalian Hibernation

A study published in eLife has revealed new insights into the molecular mechanisms underlying hibernation in mammals. The research suggests that myosin, a motor protein involved in muscle contraction, plays a role in non-shivering thermogenesis during hibernation. The study found that changes in the proportion of myosin in different resting states may contribute to reduced energy use during hibernation. The findings also indicate that small hibernating mammals experience increased ATP consumption during torpor, potentially as a response to cold exposure. Additionally, the study highlights the importance of further research into muscle samples from different areas of hibernating animals to validate these findings.

via Phys.org|

#biology #energy-consumption #hibernation