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Mucosal Immunity

All articles tagged with #mucosal immunity

Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice
science3 days ago

Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice

A nasal vaccine candidate that trains frontline lung immunity shows promise in mice for broad protection against multiple respiratory infections (cold viruses, flu, and COVID) by boosting alveolar macrophages and T cells rather than targeting a single pathogen; it may also dampen allergic reactions. Human safety and efficacy remain unproven, and the best-case path to a human-ready vaccine is five to seven years, with protection in mice lasting up to about three months and many unknowns, including effects in older adults and on DNA viruses.

via The Conversation|
#alveolar-macrophages#mucosal-immunity#nasal-spray
Dental Floss as a Needle-Free Vaccine Delivery Method
health6 months ago

Dental Floss as a Needle-Free Vaccine Delivery Method

Researchers have developed a novel method of vaccine delivery using dental floss, which could provide an effective, needle-free alternative to traditional injections and nasal sprays, especially targeting mucosal surfaces to enhance immune response. The study demonstrated promising results in mice, with potential applications in humans, though limitations such as age restrictions and infection considerations remain.

via Gizmodo|
#dental-floss#health#innovative-healthcare
science-and-technology2 years ago

"Inhaled Vaccines: Boosting Protection and Advancing Technology for COVID Prevention"

A study conducted on rhesus macaques has shown that intratracheal boosting with a bivalent Ad26-based SARS-CoV-2 vaccine enhances mucosal humoral and cellular immunity, providing near complete protection against SARS-CoV-2 BQ.1.1 challenge. This novel immunization strategy induced robust mucosal immune responses, including neutralizing antibodies, binding antibodies, and T cell responses, surpassing those induced by intramuscular and intranasal boosting. The findings suggest that developing vaccines that target mucosal immunity could be effective in blocking respiratory viral infections.

via Nature.com|
#intratracheal-boosting#macaques#mucosal-immunity
Inhalable Dry Powder COVID Vaccine: China's Groundbreaking Advancement
health2 years ago

Inhalable Dry Powder COVID Vaccine: China's Groundbreaking Advancement

A new study published in Nature reports on a promising next-generation COVID-19 vaccine that can be inhaled as a dry powder, bypassing the need for cold chains and injections. The current injectable vaccines are less effective in preventing infection by evolving variants and inducing immunity in the airway mucosal tissues. This inhalable dry powder vaccine shows potential in inducing robust immunity in the respiratory mucosal tissues, which is the site of SARS-CoV-2 entry. It could be particularly beneficial for high-risk populations and eliminate the need for frequent booster injections.

via Nature.com|
#covid-19#dry-powder#health
Nasal COVID vaccine shows promise.
health2 years ago

Nasal COVID vaccine shows promise.

Clinical trials are underway for an intranasal COVID-19 vaccine that is administered by spraying into the nose, not injecting into the arm. The hope is that a nasal vaccine would be even better at preventing mild illness by inducing immunity in the mucosa of the nasal pharynx, the site of initial viral replication, and may prevent infection and reduce transmission. Nasal vaccines work to immediately strengthen antibodies in the mucus and nose, preventing infection before the virus is able to spread throughout the body. While nasal vaccine doses have already been approved for use in some other parts of the world, they are still in the early stages of human trials in the U.S.

via NewsNation Now|
#clinical-trials#covid-19#health