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Alveolar Macrophages

All articles tagged with #alveolar macrophages

science1 day ago•12 min saved

Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice

A nasal vaccine candidate that trains frontline lung immunity shows promise in mice for broad protection against multiple respiratory infections (cold viruses, flu, and COVID) by boosting alveolar macrophages and T cells rather than targeting a single pathogen; it may also dampen allergic reactions. Human safety and efficacy remain unproven, and the best-case path to a human-ready vaccine is five to seven years, with protection in mice lasting up to about three months and many unknowns, including effects in older adults and on DNA viruses.

via The Conversation|

#alveolar-macrophages #mucosal-immunity #nasal-spray

health8 months ago•0 min saved

COPD Patients Show Higher Lung Carbon Levels Than Smokers

A recent study found that people with COPD have significantly more carbon particles in their lungs than smokers, with larger and more carbon-laden alveolar macrophages, indicating greater soot accumulation in COPD patients.

via The Washington Post|

#alveolar-macrophages #carbon-buildup #copd

health2 years ago•2 min saved

"Gut Microbiota's Impact on Respiratory Viral Infection Severity"

A study from the Center for Translational Antiviral Research at Georgia State University reveals that the composition of gut microbiota influences the severity of respiratory viral infections in mice. Specifically, segmented filamentous bacteria in the intestines protected mice against influenza, respiratory syncytial virus, and SARS-CoV-2 infections by reprogramming immune cells in the lungs called basally resident alveolar macrophages. The presence of this bacterial species altered the macrophages to resist infection and inflammatory signaling, highlighting the complex interactions between the intestinal microbiota and the severity of respiratory virus infections.

via Medical Xpress|

#alveolar-macrophages #gut-microbiota #health