"Identification of Turner Syndrome in Ancient Genomes"
Originally Published 2 years ago — by Nature.com
A new computational method has been developed to identify chromosomal aneuploidies, including sex chromosome karyotypes and autosomal aneuploidies, in ancient genomes. The method was applied to ancient British data, revealing the oldest known instance of mosaic Turner syndrome, individuals with Klinefelter syndrome, and an individual with 47,XYY syndrome, providing insights into the historical prevalence of these conditions. The study sheds light on the societal treatment of individuals with aneuploidies in ancient societies and highlights the potential for exploring past gender variability and societal perceptions of individuals with disorders of sex development.