Reducing dietary isoleucine, an essential amino acid, in mice extended their lifespan by up to 33%, improved health markers, and reduced age-related issues, suggesting potential anti-aging benefits for humans, though further research is needed.
Scientists found that reducing the amino acid isoleucine in mice diets extended their lifespan by about 33%, improved health markers, and decreased cancer incidence, suggesting that targeting specific nutrients could promote longevity without strict calorie restriction.
New research challenges the idea that all calories are equal, suggesting that reducing isoleucine in the diet can lead to significant health benefits such as extended lifespan, reduced frailty, and lower cancer rates, even with increased calorie consumption. The study in mice showed that cutting down isoleucine led to leaner bodies, increased calorie burning, steadier blood sugar levels, and reduced age-related prostate enlargement and cancer risk. While humans need isoleucine to live, the findings point toward potential dietary interventions for improving human health and understanding the biological processes involved.