UCB's shares hit a record high after positive trial results for its drug Bimzelx, while MoonLake's stock plummeted following disappointing late-stage trial data for its drug sonelokimab, which showed inferior efficacy in treating hidradenitis suppurativa.
MoonLake Immunotherapeutics' stock plummeted over 88% after its skin disease treatment, sonelokimab, showed only mixed results in clinical trials for hidradenitis suppurativa, with only one of two studies meeting its goal and a higher-than-expected placebo response, leading to investor disappointment.
MoonLake Immunotherapeutics reported failure in its Phase 3 trials for the autoimmune skin condition hidradenitis suppurativa, leading to a sharp decline in its stock price. Despite some statistical significance in one study, the drug sonelokimab did not meet the efficacy benchmarks required to compete with existing treatments, casting doubt on its commercial prospects.
A French multicenter study suggests that GLP-1 receptor agonists, drugs originally for type 2 diabetes, may reduce symptoms of hidradenitis suppurativa, a chronic skin condition, potentially through weight loss and anti-inflammatory effects, but further clinical trials are needed.
Cydney Carter shares her experience with hidradenitis suppurativa (HS), a rare and painful skin condition that causes pus-filled bumps in skin fold areas, leading to delayed diagnosis and a lack of treatment options. After years of secrecy and misdiagnosis, Carter hopes to raise awareness of HS to help others avoid the stigma and shame associated with the condition. Dr. Jenny Hsiao emphasizes the need for increased awareness and education among healthcare providers to improve diagnosis and offer better treatment options for patients with HS.
A global study conducted by the ALL Project reveals that 42% of patients with skin disease suffer from sleep disturbances, leading to a significant deterioration in their quality of life. The study also highlights the impact of living with hidradenitis suppurativa, a painful skin condition, which causes feelings of stigmatization and affects self-perception, relationships, and daily lives. The findings emphasize the need for early detection and effective management of sleep disorders in patients with skin diseases. Healthcare providers should include questions about sleep disorders in examinations to promote a comprehensive understanding of the impact of skin diseases and improve patients' well-being.
Selina Ferragamo, a 28-year-old woman from New York, has been diagnosed with hidradenitis suppurativa, a rare and painful inflammatory skin condition that causes boil-like bumps to break out all over her body. Despite altering her diet, undergoing surgeries, and taking medication, there is currently no cure for the condition. Ferragamo faces cruel comments from others who mistake her condition for herpes or skin mites, leading to feelings of depression and anxiety. She is working to raise awareness for the condition and urges fellow sufferers to seek proper diagnosis and not blame themselves for the uncontrollable disease.
Researchers have identified two genes, SOX9 and KLF5, that are associated with the development of hidradenitis suppurativa (HS), a chronic skin disease. The study conducted a genome-wide association study (GWAS) and found that variants in these genes may alter the expression of nearby genes involved in hair follicle and epidermal differentiation, as well as inflammation. The findings provide insights into the genetic basis of HS and potential targets for future treatments.
Selina Ferragamo lived with painful lumps on her armpits and groin for years before being diagnosed with hidradenitis suppurativa (HS), a chronic inflammatory skin disease. HS can be difficult to diagnose and often leads to misdiagnosis. Ferragamo's journey included painful doctor's visits and surgeries that exacerbated her condition. However, with medication, lifestyle changes, and support from her boyfriend, she has seen improvements in her symptoms. HS not only causes physical pain but also takes a toll on mental health. Ferragamo has found solace in connecting with others who have HS and has used humor and advocacy to raise awareness about the condition.