All articles tagged with #genetic manipulation
CNN's Dr. Sanjay Gupta explores the potential of pig-to-human transplants as a solution to the organ crisis, highlighting the ethical questions surrounding genetic manipulation and our relationship with animals. With 17 people in the US dying daily while waiting for an organ, some scientists and doctors argue that this controversial approach is a necessary response to a life-or-death problem.
Researchers at The Novo Nordisk Foundation Center for Biosustainability have developed a new CRISPR-Cas toolkit called "pAblo·pCasso," which enables precise and reversible DNA edits within Gram-negative bacteria, expanding the range of genome sites available for base-editing and accelerating the development of bacteria for various bioproduction applications. This technology overcomes limitations of traditional CRISPR systems by not requiring specific PAM sequences and offering reversible editing capability, revolutionizing bacterial engineering and genetic manipulation.
Researchers have developed a new algorithm called FLSHclust to search for CRISPR-Cas-like systems in genomes, leading to the discovery of 188 new CRISPR-Cas systems. These systems include enzymes with never-before-seen domains and fusions with known genes, as well as proteins with different functionalities linked to CRISPR arrays. The study highlights the vastness and untapped potential of Earth's biodiversity and provides a starting point for the development of new biotechnologies.
Scientists have made a breakthrough in understanding the unusual lifestyle of Patescibacteria, a group of elusive and poorly understood microbes. By genetically manipulating these bacteria, researchers have identified the genes essential for their growth and revealed some of the molecular mechanisms behind their interaction with host bacteria. This discovery opens up new research directions and sheds light on the "microbial dark matter" found in genetic analyses of microbial communities. The study focused on Saccharibacteria, which inhabit various environments including the human mouth, and uncovered cell surface structures and secretion systems that facilitate their attachment to host cells and nutrient transport. Further genetic manipulation studies are expected to uncover more about the biological mechanisms of these mysterious bacteria.
Researchers have made a breakthrough in understanding the lifestyle of Patescibacteria, a group of tiny microbes that rely on other bacteria to survive. By genetically manipulating these bacteria, scientists have gained insight into their molecular mechanisms and identified genes essential for their growth. This research sheds light on the "microbial dark matter" found in genetic analyses of microbial communities and has potential applications in biotechnology. The study focused on Saccharibacteria, which inhabit the human mouth and require Actinobacteria as hosts. The findings reveal the complex lifecycle of Saccharibacteria and open the door to further exploration of their unique biology.