Tag

Fgf21

All articles tagged with #fgf21

healthcare2 years ago

NASH Drug Developers 89Bio and ETNB See Promising Results in Mid-Stage Trials

89bio's Phase IIb data showed its drug, an analog of FGF21, was better than placebo at lessening fibrosis without worsening NASH in two of three dose groups. The data pave the way for a potential Phase III, following in the footsteps of another biotech in its drug class, Akero Therapeutics. To fund a late-stage study, 89bio "would need to raise additional capital," with the company having about $188 million at the end of last year.

health2 years ago

Injection Developed to Rapidly Sober Up Drunk Individuals

Researchers have discovered that the hormone fibroblast growth factor 21 (FGF21) can counteract the effects of intoxication in mice, increasing alertness in the brain and fighting against certain effects of drunkenness without fundamentally changing how alcohol is broken down in the body. The liver produces the hormone in both mice and humans, suggesting these results could apply to us, too. The hormone could be used to rouse people suffering from alcohol poisoning or extreme drunkenness so that they could be better treated. Further research is needed to demonstrate these effects in humans.