All articles tagged with #bile acids
Scientists at the Salk Institute found that bile acids, especially ursodeoxycholic acid (UDCA), influence immune cell function in the liver and could enhance immunotherapy effectiveness against liver cancer, with UDCA supplements already approved for other liver conditions offering a promising therapeutic avenue.
A new study suggests that the hormone INSL5, released when bile acids reach the large intestine, may be a key trigger for 40% of IBS-D cases, opening potential for targeted treatments and improved diagnosis.
Researchers at UC San Diego have discovered thousands of previously unknown bile acids, shedding light on the biochemical language used by gut microbes to communicate with the body. These bile acids, which are produced by the liver and metabolized by gut microbes, play a crucial role in digestion, immune regulation, and metabolic functions. The findings, likened to a "molecular Rosetta Stone," could revolutionize our understanding of human metabolism and disease treatment. The study, published in Cell, was made possible by the Collaborative Microbial Metabolite Center at UC San Diego and could lead to significant breakthroughs in the field of microbial metabolomics.
High-fat diets may be contributing to the increasing rates of colorectal cancer in young Americans, according to a study by researchers at the Salk Institute and the University of California, San Diego. The study found that high-fat diets alter gut bacteria and bile acids in mice, leading to inflammation and an increased risk of colorectal cancer. While the study was conducted in mice, it provides insight into the potential causes of the colorectal cancer epidemic in young people. Other factors such as sugar, C-sections, and fungal infections have also been suggested as possible causes.