Tag

Ecdna

All articles tagged with #ecdna

science17 days ago•7 min saved

N4BP2 enzyme sparks catastrophic cancer genome reshuffling

UC San Diego researchers have identified the enzyme N4BP2 as the trigger of chromothripsis, a chromosome-shattering event that can drive rapid cancer evolution and treatment resistance. In micronuclei, N4BP2 fragments DNA; removing it reduces chromothripsis in brain cancer cells, and higher N4BP2 activity correlates with more chromothripsis and ecDNA across thousands of tumors, suggesting N4BP2 or its pathways could be targeted to slow cancer progression.

via ScienceDaily|

#cancer #chromothripsis #ecdna

science1 year ago•9 min saved

Stanford's Cancer Breakthrough: Targeting Rogue ecDNA Defies Mendel's Law

Stanford Medicine researchers have discovered that extrachromosomal DNA (ecDNA), previously considered insignificant, plays a crucial role in cancer development. Their studies reveal that ecDNA is present in 17.1% of tumors and can drive cancer growth by containing oncogenes and immune-modulating genes. This challenges Mendel's law of independent assortment, as ecDNA can be inherited together, enhancing cancer cell survival. The research also identifies a potential cancer therapy targeting ecDNA, with a CHK1 inhibitor currently in clinical trials.

via SciTechDaily|

#cancerresearch #cancertherapy #ecdna

science1 year ago•9 min saved

Unlocking the Secrets of Circular DNA: A New Hope for Cancer Treatment

New research funded by Cancer Grand Challenges reveals how extrachromosomal DNA (ecDNA) gives tumors an advantage by housing cancer-driving genes outside chromosomes, violating Mendel's laws of inheritance. Studies led by Howard Y. Chang and Paul Mischel show that ecDNA enhances gene expression and contributes to cancer's resilience and adaptability. The research also suggests potential therapies targeting ecDNA, with a biotech company developing treatments to exploit ecDNA's transcription-replication conflicts. The findings highlight ecDNA's significant role in cancer progression and treatment resistance.

via Howard Hughes Medical Institute|

#cancer #ecdna #genetics

health1 year ago•8 min saved

Breakthrough in Cancer Treatment: Targeting Rogue DNA Circles

Stanford Medicine researchers have discovered that extrachromosomal DNA (ecDNA) circles, previously considered insignificant, play a crucial role in cancer development. Their studies, published in Nature, reveal that ecDNAs are prevalent in 17.1% of tumors and are linked to cancer progression and drug resistance. The research also highlights a novel inheritance mechanism of ecDNAs that challenges traditional genetic laws. A new therapy targeting these DNA circles is in clinical trials, offering hope for treating cancers with ecDNA-driven oncogene amplifications.

via Medical Xpress|

#cancer #ecdna #genetics