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Clemastine

All articles tagged with #clemastine

health2 years ago

Promising Medication Shows Potential to Reverse Multiple Sclerosis

Scientists have used MRI scans to demonstrate the brain repair effects of clemastine, an antihistamine, in patients with multiple sclerosis (MS). The study found that clemastine increased myelin water, indicating myelin repair, even after the medication was discontinued. This innovative method of measuring myelin water fraction offers imaging-based evidence of myelin restoration and could be used to evaluate the efficacy of future therapies for MS. The findings highlight the potential for clemastine and the importance of focusing on myelin repair beyond visible lesions. Further research will explore clemastine's potential in treating myelin damage in premature infants.

via SciTechDaily|
#brain-repair#clemastine#health
health2 years ago

New Developments in MS Research: Clemastine, Retrospective Analysis, and PIPE-791

Researchers have found evidence of myelin repair induced by clemastine based on MRI data from the ReBUILD trial, but it can only be partially effective at the doses currently being used and can have a sedative effect. A retrospective opinion piece discusses the challenges that remain in treating MS despite the gains made in recent decades. The PIPE-791 study, a potential treatment aimed at protecting damaged myelin, has been cleared for a Phase 1 study in healthy volunteers.

via Multiple Sclerosis News Today|
#clemastine#clinical-trials#health
health2 years ago

Estriol treatment promotes remyelination in MS brain.

An analysis of MRI data from the ReBUILD clinical trial has shown that the over-the-counter antihistamine clemastine can repair myelin, the protective coating on nerve fibers that’s damaged in multiple sclerosis (MS). The study provides the first direct, biologically validated, imaging-based evidence of myelin repair induced by clemastine. MRI techniques have been developed to measure the myelin water fraction (MWF), the ratio of water trapped within the thin layers of myelin to the total water content in brain tissue, most of which can flow more freely.

via Multiple Sclerosis News Today|
#clemastine#clinical-trials#health
health2 years ago

Antihistamine shows promise in repairing damaged nerves for multiple sclerosis treatment.

Researchers from the University of California, San Francisco, have found that clemastine, an over-the-counter antihistamine used to treat hay fever and allergy symptoms, could repair damaged brain nerves and reduce myelin damage in multiple sclerosis (MS) patients. The drug stimulates myelin-making stem cells, leading to an increase in myelin water in the brain, which indicates myelin repair. This is the first direct, biologically validated, imaging-based evidence of myelin repair induced by clemastine, setting the standard for future research into remyelinating therapies.

via Daily Mail|
#brain-repair#clemastine#health
neuroscience2 years ago

Antihistamine Shows Promise in Reversing Multiple Sclerosis.

A new study has identified the over-the-counter antihistamine, clemastine, as an effective drug for brain repair in Multiple Sclerosis (MS) patients. Using a newly-developed MRI scan technique, scientists were able to observe and measure the impact of clemastine on brain myelin levels. The study offers the first documented example of brain repair for a chronic neurological condition through MRI and is expected to set a standard for future research into myelin-rebuilding therapies. Clemastine is also being considered for use in treating brain injury in premature infants, who often experience myelin damage.

via Neuroscience News|
#brain-injury#clemastine#mri