The University of Pennsylvania and Inovio Pharmaceuticals are conducting a clinical trial for a vaccine aimed at preventing cancer in individuals with the BRCA gene mutation, which significantly increases the risk of breast, ovarian, prostate, and pancreatic cancer. The vaccine uses DNA and electric shocks to train the immune system to recognize and attack abnormal cells before they develop into tumors. The trial has drawn significant interest and could potentially offer a less invasive and more effective alternative to preventive surgeries and ongoing screening for those at high risk of hereditary cancer.
Country singer Morgan Wade plans to undergo a double mastectomy in November after testing positive for the BRCA gene mutation, which significantly increases the risk of developing breast cancer. Around 50% of women with the mutation will develop breast cancer by age 70. Wade, who plans to continue performing until her surgery, is optimistic about her recovery. The BRCA1 and BRCA2 genes are passed on by a person's mother and father, and if either has the gene mutation, their child has a 50% chance of also having the mutation.
Former Today show correspondent Jenna Wolfe revealed on Instagram that she underwent a hysterectomy after testing positive for the BRCA-1 breast cancer gene. The BRCA genes are tumor-suppressing, and when working properly, they keep breast, ovarian and other types of cells from growing, changing or dividing rapidly. Mutations in the genes, however, can lead to an increased risk of cancer. Women with the BRCA1 gene are at higher risk for an aggressive form of uterine cancer and thus may opt for a prophylactic hysterectomy. Wolfe's followers applauded her candor and shared their own experiences with preventative surgeries.
