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Alternative Splicing

All articles tagged with #alternative splicing

health-and-medicine1 year ago•4 min saved

"New Study Links Rapidly Aging Brain Cells to Alzheimer's Disease"

New research suggests that different versions of RNA molecules, created through a process called alternative splicing, may play a significant role in Alzheimer's disease. The study identified 700 previously unknown RNA isoforms in human brain tissue, with nearly 100 showing different levels in Alzheimer's patients compared to those without the disease. This discovery could lead to new treatments and early detection methods for Alzheimer's.

via Livescience.com|

#alternative-splicing #alzheimers-disease #brain-research

science-and-technology2 years ago•5 min saved

"Breakthrough: Low-cost Technology Enables Precise Long-Read RNA Sequencing"

Researchers at Children's Hospital of Philadelphia (CHOP) have developed TEQUILA-seq, a versatile and low-cost technology for targeted sequencing of full-length RNA molecules. This technology allows for accurate accounting of transcript isoforms, which is crucial for understanding alternative splicing and its role in diseases like cancer. TEQUILA-seq utilizes a cost-effective method for synthesizing capture probes and can be adapted for different research and clinical purposes. It has the potential to accelerate the discovery of new diagnostics and treatments for various diseases.

via Phys.org|

#alternative-splicing #diagnostics #rna-sequencing