"Breakthrough: Low-cost Technology Enables Precise Long-Read RNA Sequencing"

Researchers at Children's Hospital of Philadelphia (CHOP) have developed TEQUILA-seq, a versatile and low-cost technology for targeted sequencing of full-length RNA molecules. This technology allows for accurate accounting of transcript isoforms, which is crucial for understanding alternative splicing and its role in diseases like cancer. TEQUILA-seq utilizes a cost-effective method for synthesizing capture probes and can be adapted for different research and clinical purposes. It has the potential to accelerate the discovery of new diagnostics and treatments for various diseases.