All articles tagged with #aldosterone
Many patients with high blood pressure are undiagnosed with primary aldosteronism, a hormone-driven condition that increases cardiovascular risks; early testing and treatment can significantly improve outcomes.
Researchers at Queen Mary University of London and Barts Hospital have identified a gene variant that causes a common type of hypertension and a way to cure it. The cause is a tiny benign nodule, present in one-in-twenty people with hypertension, that produces a hormone called aldosterone. The gene variant affects a protein called CADM1 and leads to a vast, but intermittent, over-production of the hormone. This form of hypertension could be cured by unilateral adrenalectomy. The researchers recommend measuring aldosterone through a 24-hour urine test to discover more people living with undiagnosed hypertension.
Researchers have identified a gene variant that causes a common type of hypertension and a way to cure it through unilateral adrenalectomy, removing one adrenal gland. The condition is caused by a tiny benign nodule that produces a hormone, aldosterone, which controls how much salt is in the body. The gene variant affects a protein called CADM1 and stops cells in the body from ‘talking’ to each other and saying that it is time to stop making aldosterone. The researchers recommend that aldosterone is measured through a 24-hour urine test rather than one-off blood measurements for improved hypertension diagnosis and treatment.
Researchers at Queen Mary University of London have discovered a gene variant that causes hypertension in some patients. The variant affects a protein called CADM1 and leads to intermittent over-production of the hormone aldosterone, causing salt overload and hypertension. The researchers recommend measuring aldosterone through a 24-hour urine test to identify more people living with hypertension but going undiagnosed. The condition can be cured by removing one of the two adrenal glands. The research was funded by Barts Charity and undertaken by research fellows funded by the British Heart Foundation, National Institute of Health Research, Medical Research Council, and Royal Society.
Researchers have discovered a gene variant in a tiny benign nodule that causes a common type of high blood pressure in one-in-twenty people with hypertension. The variant affects a protein called CADM1 and causes fluctuating release of aldosterone throughout the day, making it hard for doctors to diagnose some patients with hypertension. The researchers also discovered that this form of hypertension could be cured by unilateral adrenalectomy—removing one of the two adrenal glands. The discovery recommends aldosterone be measured through a 24-hour urine test rather than one-time blood measurements, which will reveal more people living with hypertension but going undiagnosed.
Doctors at Queen Mary University of London, Barts Hospital, and Cambridge University Hospital have developed a new CT scan to detect hormone-producing nodules in a gland, which is found in one-in-twenty people with high blood pressure. The scan, when combined with a urine test, detects a group of patients who can stop all their blood pressure medicines after treatment. The research solves a 60-year-old problem of detecting nodules without a difficult catheter study.