All articles tagged with #3d genome organization
This study uses in situ single-cell chromatin tracing to map 3D genome changes during Kras-driven lung and pancreatic cancers, revealing stage-specific conformational alterations that can distinguish cancer states, identify prognostic genes, and uncover regulators like Rnf2 that influence genome architecture and tumor progression.
The study uses ultra-high-resolution Micro-C mapping to reveal complex 3D structures in the E. coli genome, including transcription-dependent domains called OPCIDs and repressive structures called CHINs and CHIDs, which are primarily assembled on horizontally transferred genes and regulated by nucleoid-associated proteins like H-NS. These structures influence gene expression and genome stability, with H-NS playing a central role in their formation and maintenance.