Unraveling the Regulatory Activity of DNA Across Species

New research reveals that while yeast cells actively transcribe nearly all genes, mammalian cells naturally repress transcription, challenging our understanding of genetic transcription across species. The study involved inserting a synthetic gene in reverse order into yeast and mouse stem cells, uncovering significant differences in transcription activity. Understanding these default transcription differences across species could guide genetic engineering efforts and help in the discovery of new genes.