"NICER: Revolutionizing Gene Editing with Enhanced Safety"

Researchers in Japan have developed a new gene editing technique called NICER, which is as effective as CRISPR/Cas9 but significantly reduces unintended DNA mutations. NICER uses an enzyme called a nickase to create multiple small cuts in single DNA strands, promoting interhomolog homologous recombination to correct heterozygous mutations. The technique has shown promising results in restoring gene expression in cells derived from genetic diseases involving compound heterozygous mutations. NICER represents a safer alternative to conventional CRISPR/Cas9 methods for the treatment of genetic diseases.