Innovative Gas and Ultrasound Techniques Enhance Blood-Brain Barrier for Safer Brain Drug Delivery

Researchers at UT Southwestern discovered that nitrous oxide can safely enhance the delivery of gene therapy to the brain by making the blood-brain barrier more permeable with focused ultrasound, using significantly lower microbubble concentrations and ultrasound pressures, which reduces tissue damage risk and improves gene delivery efficiency in mouse models, paving the way for potential clinical trials for neurological diseases.