Gene Therapy Targets Pain Circuits to Relieve Chronic Pain Without Addiction
TL;DR Summary
A preclinical CNS-targeted gene therapy dampens pain signals in specific brain circuits to relieve chronic pain while avoiding the brain reward pathways tied to addiction, using AI-guided imaging and animal models, with an off switch for long-lasting relief and moving toward clinical trials to help the roughly 50 million Americans affected by chronic pain.
- Beyond Opioids: The New Gene Therapy That Relieves Pain Without the Addiction SciTechDaily
- Mimicking opioid analgesia in cortical pain circuits Nature
- Gene therapy ‘switch’ may offer non-addictive pain relief Technology Org
- Preclinical stage gene therapy targets brain's pain circuits without risks of opioid addiction Labmate Online
- Gene therapy breakthrough could provide hope for millions living with chronic pain News-Medical
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